The PlasmacureTM filters are Plasma separators. utilizing these membrane plasma separators plasma components and blood cells are separated depending on their size in plasma separation utilizing a membrane plasma separator. In this way, the plasma can be completely removed or treated. Plasma Separators can be used to separate plasma and blood cells in various plasmapheresis treatments: the Plasma Exchange (PEX) and the Double Filtration Plasmapheresis (DFPP).
The EvaclioTM filters are high cut-off filters, available in 4 models, with a different pore size distribution. Pores of all these models are significantly small in size compared to those of the conventional plasma separators. This results in smaller loss of high-molecular-weight substances such as albumin, immunoglobulins and coagulation proteins.
The EvafluxTM filters are fractionator filter. The availability of 4 different cut-offs makes possible the removing of pathogens related to their molecular weight in semi-selective way.
Comparison between Membrane Plasma Separation and Centrifugal Plasma Separation
No platelet contamination is observed in plasma separation utilizing membrane plasma separators, such as PLASMACURETM.
Protein rejection curve, in vitro tests
Double Filtration Treatments are the result of the combined use of PlasmacureTM and EvafluxTM filters.
Benefits of Double Filtration treatments:
- Selective depletion of plasma components based on their molecular size
- Reduced or no requirement for substitution fluid (FFP – Fresh Frozen Plasma; Albumin Sol.): lower risk of infection than in PEX treatments.
- Treating high volumes of plasma, higher than in PEX treatments.
- Semi-selective plasma components removal: wide range of indications, removal efficiency depending on plasma fractionators pore size.