SARS-CoV-2 infection in kidney transplant recipients: experience of the Italian Marche region

This case series included 5 patients who were kidney transplant recipients (KTR) and also SARS-CoV-2 (COVID-19) positive. One of the patients developed acute kidney injury with the need for continuous renal replacement therapy (CRRT) where CytoSorb was also used for 3 x 24hr treatments. The authors speculate that use of CytoSorb in this patient for removal of the initially very high interleukin 6 levels, could potentiate the effect of tocilizumab, an IL6 receptor agonist. Indeed, during CRRT treatment plus CytoSorb, the patient’s hemodynamic and hypoxemic conditions improved. Finally, it is suggested that the use of CytoSorb in combination with tocilizumab might be considered in patients with severe SARS-CoV-2 with need of CRRT.

Open-access publication: https://pubmed.ncbi.nlm.nih.gov/32573895/

Maritati F, Cerutti E., Zuccatosta L, Fiorentini A, Finale C, Ficosecco M, Cristiano F, Capestro A, Balestra E, Taruscia D, Vivarelli M, Donati A, Perna GP, Giacometti A, Tavio M, Onesta M, Di Sante L, Ranghino A; Transpl Infect Dis 2020: e13377