Respiratory failure

“Hypercapnic respiratory failure can be managed with extracorporeal techniques for CO2 removal”.

Respiratory failure refers to a dysfunction of the respiratory system where proper gas exchange and the maintenance of adequate levels of oxygen and/or carbon dioxide in the blood are not ensured.

Respiratory failure

Both invasive mechanical ventilation with protective volumes and non-invasive ventilation aim to preserve lung physiology from the damage caused by ventilation but may lead to the accumulation of CO2 in the lungs and subsequent development of severe hypercapnia and respiratory acidosis.

Hypercapnic respiratory failure can be treated and prevented using extracorporeal CO2 removal techniques.

HYPERCAPNIC Respiratory Failure

ARDS (Acute Respiratory Distress Syndrome): a clinical condition characterized by pulmonary inflammation that compromises the functionality of the alveoli and their ability to assimilate oxygen from inspired air;

ARF (Acute Respiratory Failure): a clinical condition characterized by the inability of the pulmonary system to properly exchange gases;

VILI (Ventilator Induced Lung Injury): lung damage induced by invasive ventilation conducted at positive pressure and high gas exchange volumes;

ALI (Acute Lung Injury): acute lung damage characterized by compromise of the alveolar capillaries leading to severe respiratory failure with refractory arterial hypoxemia despite oxygen administration;

Pneumonia: a lung pathology characterized by inflammation of the alveoli, which fill with fluid that obstructs respiratory function;

Trauma or Polytrauma: one or more traumatic injuries to different organs or systems with current or potential compromise of vital functions;

MODS (Multiple Organ Dysfunction Syndrome): a systemic syndrome generally associated with shock, sepsis, or systemic inflammatory response syndrome (SIRS), characterized by acute onset of organ function alteration;

COPD (Chronic Obstructive Pulmonary Disease) and exacerbations: a chronic lung disease characterized by bronchial obstruction, with partially or irreversibly limited airflow, slowly progressive, caused by chronic inflammation of the airways and lung parenchyma.

Molecules to remove: CO2
Recommended Therapies: ECCO2R

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