The PerLungs
® kit consists of oxygenators, leucocyte filters and centrifugal pumps to allow reperfusion of the lung, in a controlled environment, using dedicated solutions to support its metabolic needs.
The application of purification systems by adsorption of the perfusion solution it’s the core of the system. Numerous findings in the literature emphasise, in fact, the role played by a series of substances developed during ischaemia and put into circulation during reperfusion, first and foremost the inflammatory mediators, potentially capable of compromising organ function and leading to organ dysfunction 1,2,3,4. Removal by adsorption (PerSorb®) of these substances can therefore be decisive in the recovery of organ function and subsequent successful transplantation.
The PerLungs® Kit is designed to meet the specific needs of the centre using it, so that it can be applied with any extracorporeal circulation equipment.
1 Andreasson A.S.I., Borthwick L.A., Gillespie C., Jiwa K., Scott J., et Al. The role of interleukin-1β as a predictive biomarker and potential therapeutic target during clinical ex vivo lung perfusion. J Heart Lung Transplant. 2017 Sep; 36(9): 985–995.
2 Andreasson A.S.I., Karamanou D.M., Gillespie C.S., Özalp F., Butt T., et Al. Profiling inflammation and tissue injury markers in perfusate and bronchoalveolar lavage fluid during human ex vivo lung perfusion. Eur J Cardiothorac Surg. 2017 Mar; 51(3): 577–586.
3 Solidoro P., Schreiber A., Boffini M., Braido F., Di Marco F. Improving donor lung suitability: from protective strategies to ex-vivo reconditioning. Minerva Med. 2016 Jun;107(3 Suppl 1):7-11.
4 Boffini M, Marro M, Simonato E, Scalini F, Costamagna A, Fanelli V, Barbero C, Solidoro P, Brazzi L, Rinaldi M. Cytokines Removal During Ex-Vivo Lung Perfusion: Initial Clinical Experience. Transpl Int. 2023 Aug 14;36:10777. doi: 10.3389/ti.2023.10777. PMID: 37645241; PMCID: PMC10460908.
