PerSorb®
Immunomodulation: A New Paradigm in Ex-Situ Organ Reconditioning
Ex-situ perfusion is presented as a strategy to increase the suitability of organs for transplantation by maintaining the organ in a controlled physiological-like environment. Due to various factors, important inflammatory processes can be triggered, which contribute to the progression of organ damage, thus limiting transplantability and successful transplantation.
Remodulation of the inflammatory response, even during ex-situ perfusion, therefore plays a key role in limiting organ damage, thus favouring a successful outcome of the procedure.
PerSorb® in summary
With PerLife®, ex-situ perfusion can be combined with the purification of the perfusion fluid from inflammatory mediators, which are involved in the complex process of organ damage, through the integration of PerSorb®.
PerSorb® is a sorbent cartridge dedicated to the adsorption, from the perfusion fluid, of hydrophobic molecules with molecular weights up to 55 kDa during ex-situ perfusion treatments of organs intended for transplantation.
PerSorb® is based on a proprietary technology, specifically certified for this purpose and exclusively dedicated to ex-situ perfusion treatments with the PerLife® system.
Proprietary technology
PerSorb® is a sorbent based on a resin with a porous structure and characterized by polystyrene-divinylbenzene microspheres coated with polyvinylpyrrolidone, allowing the cartridge to be used on both acellular-based liquids and blood-based substrates.
The adsorption spectrum
Removal of hydrophobic molecules with molecular weights up to 55kD.
Ease of use
Easy and safe integration and use with the PerLife® system.
