PerLife^{® PRO}

The evolution of ex-situ reconditioning of abdominal organs for transplantation.

PerLife^{® PRO} is the multi-therapeutic platform dedicated to ex-situ perfusion, with organ-specific therapeutic modalities and the use of dedicated kits:

PerKidney^®

Therapeutic procedure dedicated to kidney reconditioning. *

PerLiver^®

Therapeutic procedure dedicated to liver reconditioning in HOPE or DHOPE modality. **

* Project co-financed by the European Regional Development Fund with a contribution of €131,240.23, allocated in the budget of year 2018.
** Project co-financed by the European Regional Development Fund
Medical device CE marked in accordance with EU Regulation 2017/745 (MDR)

PerLife^{® PRO} in summary

The Platform

Physiology & Versatility

Pressure-controlled perfusion for physiological-like flows, adapted to the variable conditions of the organ.

Automatic temperature control (4 °C -37 °C)

For procedures:

Hypothermic, without the use of ice (HOPE or DHOPE modalities for liver treatment)
Sub-normothermic
Normothermic
Sequential, gradually rewarming the organ in controlled conditions without interrupting the treatment, adjusting perfusion parameters, including the fluid, according to the specific thermal phase.

Sequential Automatized Liver DHOPE-COR-NMP

DHOPE-COR-NMP Sequential Automated Procedures for gradual heating of the organ with:

Hypothermia without using ice
Adjustment of fluids and perfusion parameters based on the thermal conditions of the treatment
Profiling of perfusion pressures and temperatures
Liquid exchange without interruption of treatment

Purification of perfusion fluid

Remodulation of inflammatory mediators and molecules potentially harmful to the organ. The combination of ex-situ perfusion with the PerSorb^® adsorption system allows the remodulation of levels of inflammatory mediators and molecules potentially harmful to the organ in the perfusate during ex-situ organ perfusion treatments.

Oxygenation of perfusion fluid

Effective and continuous oxygenation throughout the entire treatment duration via an oxygenation module.

Modular and integrated disposable system

Primarily structured into:
Organ container configured for:

Organ preparation (backtable)
Organ containment
Organ perfusion
Organ supervision and isolation from the surrounding environment
Separated collection of any organ products: urine (kidney) or bile (liver)

Reservoir for:
Containment and temperature regulation of the perfusion fluid without any direct contact between the organ and the equipment.
Pre-assembled and pre-connected circuits.
The dedicated circuit system allows for the most accurate and straightforward assembly, minimizing the chances of error.
Organ – and vessel-specific Cannulas
Models of different calibre and length, adaptable to the organ’s vascular system, ensure the connection of the extracorporeal circuit with the graft.

PumpProtect^®

Machine Perfusion Solution

PumpProtect^® is a medical device dedicated to ex-situ hypothermic organ perfusion of kidney or liver. It is an aseptically produced clear, sterile and pyrogen-free solution.

PerLife® PRO