The gap between organs suitable for transplant and organ demand is increasing: waiting lists are growing.
It is necessary to ensure the use of every organ, even the marginal ones, damaged by complex biological reactions and by the processes characterizing the retrieval and the storage. At the same time, there is a need to optimize the outcome of the intervention.
Ex vivo perfusion can be a strategy to increase the availability of transplantable organs. It gives the possibility to keep the retrieved organ in a controlled environment outside of the body.
Important inflammatory processes, involving some already known molecules, as inflammatory mediators, can develop in the organ at different levels of the transplant Process, influencing the progression of organ injury and thus limiting its transplantation and positive transplant outcome.
Inflammatory response modulation also during ex vivo perfusion can play a key role to limit organ injury by promoting the increase of organs suitable for transplantation and the positive outcome.
PerSorb® at a glance
PerLife® allows the combination of ex vivo perfusion with purification of the perfusion solution from inflammatory mediators, to help limiting organ injury.
PerSorb® is a sorbent cartridge dedicated to the adsorption of inflammation mediators, i.e. Hydrophobic middle sized molecules, up to 60 kDa, from perfusion solution during organ ex vivo reconditioning.
PerSorb® is specifically certified for this purpose and exclusively dedicated to ex vivo perfusion treatments with the PerLife® system.
Proprietary Technology:
PerSorb® is characterized by a resin with beads of polystyrene-divinylbenzene and polyvinylpyrrolidone.
Wide Adsorption Spectrum:
Removal of Hydrophobic middle sized molecules, up to 55kD.
Ease of use
Easy set-up and safe application in combination with PerLife® system.
