Rhabdomyolysis
“Myoglobin and CPK (Creatine Phosphokinase) have nephrotoxic effects. Their rapid adsorption allows for preservation/restoration of renal function”.
Rhabdomyolysis is a syndrome characterized by the breakdown of skeletal muscle and the release of various compounds from damaged muscle cells into the bloodstream.
Blood and urine tests reveal the release of electrolytes, myoglobin, and other plasma proteins into circulation.
In most cases, drugs and alcohol are identified as the main causative agents of rhabdomyolysis. Other causes include crush syndrome, muscle strain, extreme temperatures, ischemia, prolonged immobilization, infections, electrolyte and endocrine disorders, genetic disorders, and connective tissue disorders.
Acute kidney injury is a frequent and potentially fatal complication of rhabdomyolysis, primarily due to myoglobin accumulation in the renal tubules. Myoglobin exerts a direct cytotoxic effect on proximal convoluted tubule cells. Traditional therapies for rhabdomyolysis, including dialysis techniques, have shown only partial efficacy. Fluid administration, urine alkalization, and forced diuresis are used to protect renal function, but are not effective in cases of severe oliguria. Acute kidney failure is treated with hemodialysis, but it is crucial to remove circulating myoglobin to prevent further damage and attempt to restore renal function.
Clinical evidence supports the use of extracorporeal depurative techniques for massive and rapid removal of myoglobin and creatine kinase (CK). These methods are employed both preventively to prevent acute kidney damage and therapeutically to avoid irreversible renal damage and promote rapid recovery of function in cases of rhabdomyolysis.
Molecule to Remove: Myoglobin
Recommended Therapies: CytoSorb®