Vasculitis ANCA-associated are vasculitis of small vessels, characterized by positivity for pathogenic antibodies ANCA (antibodies against neutrophil cytoplasm). They are characterised by chronic and relapsing symptoms of varying severity and essentially include granulomatosis with polyangitis (Wegener granulomatosis) and microscopic polyangitis.
The main consequence of vasculitis is the loss of vascular integrity, which goes as far as interrupting the blood flow and thus damaging the tissues from these sprayers. The organs most frequently involved are the kidneys, the upper respiratory tract and the lungs, but also the nervous system, the skin, the musculoskeletal system, the heart, the eye and the intestine.
Treatments include administration of corticosteroids, monoclonal antibodies, plasmapheresis, up to the final stage of kidney transplantation.
Molecules to be removed:
ANCA (neutrophil anti-cytoplasm antibodies), predominantly IgG
PEX, DFPP, Cascade Filtration