ApherCap is a simple multi-therapeutic platform that allows extracorporeal treatment for respiratory failure in acute critically ill patients, in particular:
- CO2 removal (ECCO2R)
- CO2 removal in combination with hemofiltration (ECCO2R + HF)
- Emoperfusione (HP)
The goal is to support the lungs in patients undergoing either non-invasive or mechanical ventilation, providing partial CO2 removal from the blood, while oxygenation is left to the usual ventilatory techniques.
Therapies and treatments
The removal of CO2 takes place thanks to a pediatric oxygenator in PMP, also used on ECMO circuits that, with a diffusion mechanism, allows the elimination of excess CO2. It has a guaranteed duration of 5 days and is able to maintain unchanged the performances also in the long term.
The use of this method has been proposed in multiple clinical scenarios.It is in fact able to:- A protective fan strategy in patients with ARDS, mitigating the impact of mechanical ventilation induced lung damage (Ventilator-induced lung injuri, VILI)- A reduction in respiratory discomfort, avoiding the patient’s orotracheal intubation with COPD during disease exacerbations- A reduction in the incidence of tracheal intubation in severe asthma (near-fatal asthma, NFA)- The administration of temporary therapy pending lung transplantation in patients with chronic respiratory conditions.
ECCO2R in summary:
- Allows prolonged treatments up to 5 days without replacement/modification of disposable kit
- Allows variable blood flow between 30 and 450 ml/min
- User friendly interface
In the ECCO2R mode performed with ApherCap for CO2 removal can also be combined with haemfiltration, with ECCO2R+HF treatment. The blood filter, placed upstream of the oxygenator, allows adequate renal support in case of organ insufficiency, as well as optimizing the process of removal of carbon dioxide operated by the oxygenator itself.
In the ECCO2R mode performed with ApherCap for CO2 removal can also be combined with haemfiltration, with ECCO2R+HF treatment. The blood filter, placed upstream of the oxygenator, allows adequate renal support in case of organ insufficiency, as well as optimizing the process of removal of carbon dioxide operated by the oxygenator itself.
ECCO2R + HF in summary:
- Extended treatment for up to 5 days without replacement/modification of disposable kit
- FVariable blood flow between 30 and 450 ml/min
- User friendly interface
- Post-dilution infusion fluid handling
- Weight loss between 10 and 1000 gr/h and haemfiltration exchange, thanks to the presence of an automatic modular clamp
Thanks to the presence of a peristaltic pump capable of working between 30 and 450 ml/min, ApherCap is also designed to perform haemoperfusion treatments, with sorbent cartridges dedicated to adsorption, from whole blood, molecules responsible for the development of some diseases, including CytoSorb ®.