Macro-globulinaemia is an uncommon B-cell line neoplasm in which B-cells produce an excessive amount of IgM
. It is clinically more similar to lymphoma than multiple myeloma or other plasma cellular diseases. The cause is unknown, mainly affects men around the age of 65. Most patients are asymptomatic, but many have anaemia or symptoms of a hyperviscosity syndrome
: fatigue, asthenia, skin deposits, bleeding of the skin and mucous membranes, visual disturbances, headache, symptoms of peripheral neuropathy and other variable neurological manifestations.
The therapy includes plasmapheresis, with the aim of removing IgM and hyperviscosity triggers.